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This mechanism makes L-carnitine especially valuable during aerobic exercise, when the body taps into fat stores for sustained energy

The needles create temporary channels through the stratum corneum while the serum flows through the needle bore at the same time, bypassing the skin barrier that would otherwise block large molecules like peptides, growth factors, and high-molecular-weight hyaluronic acid

The understanding of this mechanism was later derived from a separate study involving mice.

PMID: 10501046

Additionally, the area under the curve (AUC) for CU in rats was found to be 3.6 0.6 min/g/mL following oral administration of 500 mg/kg, and only 7.2 1.2 min/g/mL after intravenous administration of 10 mg/kg, further indicating poor absorption characteristics (Yang et al., 2007)